【摘要】 通过抗鼠疫血清、鼠疫噬菌体、抗鼠疫噬体血清及吖啶黄的人工培养基对鼠疫强毒菌株诱变,获得了9株非典型鼠疫菌株,对其进行了生物学特性研究。采用部分非典型鼠疫菌株做了动物(豚鼠)试验,通过动物模型对带菌时间、部位及突变和返祖过程进行了研究。本文建立了诱变方法及非典型鼠疫菌的检测方法。提出了非典型鼠疫菌的流行病学意义和鼠疫监测对策以及以非典型鼠疫菌作为一种形式在自然界长期保存循环的可能性,并为根除鼠疫自然疫源性提供了一种评价方法和指征。更多还原

【Abstract】 We had obtained nine atypical strains from Y.pestis that were induced by Y. serum, Y. phage, Y. phage’s serum and artificial agar culture medium of Acridine yellow. We studied their biological features. We also studied some of these strains by animal experiment. In the same time we studied the time of carrying bacteria, location, mutation and the course of restoring virulence with animal model. On this paper we set up the inducing method and detecting method of atypical Y.pestis; put forward the epidemiological significance and the surveillance countermeasure of atypical Y. pestis. And gave a possibility of Y. pestis existing in nature for a long time. And we devoted a evoluation to rooting out plague.更多还原