【摘要】 在环磷酰胺（CTX）和⁶⁰Co—r 射线所致小鼠白细胞降低（简称低白）模型上,用黄芪口服液（AS）1.75g/kg,去除苷的黄芪口服液（NAS）1.75g/kg,黄芪甲苷（ASI）6mg/kg,绵毛黄芪苷Ⅺ（SK）3mg/kg,灌胃给药7天、20天。经与对照组相比,证明4种不同制剂黄芪均有不同程度的对抗白细胞下降,其中 ASI、SK 组 P<0.01,AS、NAS 组 P<0.05。在氢化考的松（HC）所致小鼠淋巴细胞降低的模型上,ASI 6mg/kg,SK 3mg/kg,灌胃7天,经与给 HC 合用羧甲基纤维素（CMC）组相比,证明两种黄芪苷能显著对抗 HC 所致淋巴细胞降低和脾重下降。上述实验证明黄芪苷是黄芪中调节机体免疫功能的成分。更多还原

【Abstract】 The effects of two Astragalus saponins（ASI.SK）,two Astragalus Preparations（AS,NAS）were de- scribed which contained total Astragalus saponins for AS and non-saponins for NAS,on the leukocytopenia in- duced by cyclophospharnide（CY）and ⁶⁰Co radiation.Results indicated that ASI（6 mg/kg）,SK（3 mg/kg）.AS （1.75 g/kg）,NAS（1.75 g/kg）continuously given orally for 7,20 days.significantly increased the leukocyte counts in these pathological models.7 days was need for ASI 6 mg/kg,SK 3 mg/kg to significantly relieve the leukocytopenia caused by hydrocortisone（HC）.These results showed that the two saponins were the main ef- fective immuno-regulating components which Astragalus membranaceus contained.更多还原