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济南假单胞菌细胞壁组分(PJ-CW)体内外抗癌作用的研究

The Studies on the Anti-Tumor Effect of PJ-CW both in Vitro and in Vivo

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【作者】 崔正言; 张玲; 殷际义; 李淑贞; 韩玉美; 肖东杰; 何祖泽;

【Author】 Cui Zhenyan, Zhang Ling, Yin Jiyi et al. (Department of Immunology, Shandong Academy of Medical Sciences, Jinan 250001)

【机构】 山东省医学科学院基础所免疫室!济南250001; 山东省医科院药?;

【摘要】 本文报告了PJ-CW对荷瘤小鼠移植肿瘤以及肿瘤细胞株抑制作用的研究.结果显示,PJ-CW不仅对瘤细胞(EL4)和荷瘤(S180、H22)鼠肿瘤有直接抑制和抑瘤作用,且能促进LAK细胞进入瘤组织,从而保护了荷瘤鼠的免疫器官,延长其存活期.PJ- CW制剂仅含多糖与氨基酸,注射后无发热等副作用,因此是一种有发展前途的新型抗癌生物制剂.

【Abstract】 In this article a series of experimental studies of anti-tumor effect of PJ-CW both in vitro and in vivo were carried out. The results indicated that PJ-CW can play a full role in direct inhibition to tumor cells and inhibition of tumor growth in tumor-bearing mice, and improving entrance of LAK cells into tumor tissues, protect the immune organs of tumor bearing mice and prolong its survival time. Because the preparation of PJ-CW only contains polysaccharides and aminos acid, there is no side-effect of fever after injection.Therefore PJ-CW is a new kind of BRM, which may enjoy promising perspective.

【关键词】 PJ-CW; 抗癌作用; 免疫调节; 生存期;
【Key words】 PJ-CW; anti-tumor effect; immune regulation; survival period;
  • 【文献出处】 中国肿瘤生物治疗杂志 ,Chinese Journal of Cancer Biotherapy , 编辑部邮箱 ,1995年02期
  • 【分类号】R73-36
  • 【下载频次】14
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