【摘要】 为研究特发性葡萄膜渗漏综合征的临床特征、病理表现和治疗方法，对７例１０只眼患者除进行一般临床检查外，主要采用间接检眼镜、荧光眼底血管造影及Ｂ超检查，结果提示特发性葡萄膜渗漏综合征的四大诊断依据为：周边部环形葡萄膜脱离；可移动的、非孔源性视网膜脱离；前节无明显炎症反应；眼压正常。同时可见以“豹点斑”为特征的眼底改变。所有病例均采用巩膜切除术治疗，术后近用内葡萄膜脱离消失，远期视网膜复位，视力恢复良好。对切除的５只眼巩膜行超微结构和组织化学观察，结果显示：巩膜增厚，巩膜纤维增粗，排列紊乱，层间大量氨基多糖沉着。提示巩膜先天异常是本病的基本原因。更多还原

【Abstract】 In order to investigate the clinical features,pathology and treatment of idiopathic uveal effusion syndrome,ten eyes of seven patients with the syndrome had been studied.In addition to gener-al clinical examinations,indirect opthalmoscopy,fundus fluorescein angiography and(FFA)ultrasono-graphy were used to make definite diagnoses. The findings of these examinations indicate four key fea-tures of the idiopathic uveal effusion syndrome. They are:annular cilio-choroidal detachment,shifting non- rhegmatogenous retinal detachment,unremarkable inflammation in the anterior segment,and nor-mal intraocular pressure. The fundus change is characterized by the“leopard-spot”. All patients were treated by sclerectomy and sclerotomy,ciliochoroidal detachments disappeared soon after surgery,and retinal detachments resolved later on. Patients’visual acuity recovered well.The histochemical and elec-tron microscopic examinations of excised tissues from five eyes showed thickened sclera,a general in-crease of the scleral fibril width compared to normal scleral,the disruption of normal lamellar arrange-ment of the scleral fibers and the deposition of glycosaminoglycans in the interfibrillar spaces.All these indicate that a congenital scleral abnormality seems to be the basic pathophysiology of the idiopathic uveal effusion syndrome.更多还原