【摘要】 应用酶联免疫测定法对３２例急性心肌梗塞（ＡＭＩ）病人心脏特异性肌钙蛋白Ｔ（ＴｎＴ）的释放进行了动态观察。８例ＡＭＩ病人血清ＴｎＴ的释放呈双峰性曲线，早期峰值时间约在梗塞后１０～１８小时，峰值浓度较正常上限值升高约３０～１２０倍；后期峰较为平缓，升高幅度低于早期峰，约在梗塞后７０～１００小时出现。２４例血清ＴｎＴ呈单峰性曲线，峰值约在梗塞后３２～１０８小时，峰值升高幅度明显高于双峰曲线的后期峰。血清ＴｎＴ最早升高时间约发病后在３～４小时，多数病人梗塞后第１０天左右降至正常。结果表明：血清ＴｎＴ是一项灵敏度高、特异性强的心肌损伤性血清标志物，ＡＭＩ病人血清ＴｎＴ呈双峰性变化者提示有早期再灌注，梗塞后血清ＴｎＴ１４／３２小时比值对判断有无再灌注可能有重要的参考价值；ＡＭＩ病人血清ＴｎＴ持续升高提示预后不良。更多还原

【Abstract】 Abstract In the present study, the release kinetics of cardiac specific troponin T(TnT), measured by an enzyme immunosorbent assay, in 32 patients with a acute myocardial infarction (AMI) were evaluated. In 8 AMI patients, serum TnT showed a biphasic concentration curve with a large peak at 10 to 18 hours after onset of pain with peak serum TnT concentrations up to 30 to 120 times that of the upper normal limit, and another small TnT peak at 70 to 100 hours after onset. In the remaining 24 cases only one large serum TnT peak was found 32 to 108 hours after onset of pain. TnT might appear in the serum as early as 3 to 4 hours and remained elevated up to 240 hours after onset of pain.The results indicated that (1) serum TnT is a sensitiveand specific marker for ischemic cardiac injury and its serum concentration remains high for a longer period of time after AMI; (2) the biphasic curve of TnT release,the ratio of TnT at 14 to 32 hours after onset (14/32),in particular are useful markers suggesting early reperfusion; (3) persistent elevation of serum TnT in AMI patients may be a prognostic indicator for unfavorable outcome.更多还原