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蛛网膜下腔出血后脑血管痉挛的发生机理研究

The research on the pathogenic mechanism of cerebral vasospasm following subarachnoid hemorrhage

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【作者】 刘佰运王忠诚吴建中李佑祥苏敏成

【Author】 Liu Bai yun;Wang zhongchen;Wu Jianzhong,et al.(Beijing Neurosurgical Institute, Beijing 100050)

【机构】 北京市神经外科研究所

【摘要】 本实验利用犬通过“二次枕大池注血法”建立蛛网膜下腔出血模型,并通过血管造影检查,痉挛血管的功能测试,管壁的自由基含量变化,管壁的结构改变等方面的观察,探讨了脑血管痉挛的发生机理。同时还对蛛网膜下腔出血后的血压,白细胞数和体温的变化作了观察。本文对上述的结果进行了讨论。

【Abstract】 Abstract In this experimental study, canine double subarachnoid hemorrhage (SAH) model was established by two successive injections of cisternal blood administered 72 hours apart. All animals survived until sacrifice on the 7th day after first injection. Angiograms of basilar arteries (BA) showed: At 30th minute, lst hour and 7th day after first injection, the incidences of vasospasm was 89%, 89% and 100% respectively, accompanied by an average arterial constriction of 31.7 %±15. 6% (P<0.01), 33.2 %±13.8% (P<0.01) and 47.3%±19% (P<0.001) respectively. Rings of BA obtained from SAH group contracted much more weakly than those from control group in response to vasoconstrictors(P<0.01). LPO of BA’s wall were much more in the blood group than in the saline group(P<0.01). and LPO content were consistent with the vessel wall injuries. The pathological study of BA’s wall confirmed degenerative changes in the tunica intima and media, subendothelial and medial thickening, partial myonecrotic changes ,and the leukocytic infiltration in the tunica adventitia.

【基金】 卫生部科研基金
  • 【文献出处】 中华神经外科杂志 ,CHINESE JOURNAL OF NEUROSURGERY , 编辑部邮箱 ,1995年04期
  • 【分类号】R743.350.2
  • 【被引频次】93
  • 【下载频次】323
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