【摘要】 采用血管灌流大鼠离休胃模型，探讨生长抑素对胃运动的影响。结果表明：（１）生长抑素能明显抑制胃窦自发和胃动素兴奋的胃运动；（２）生长抑素可抑制离休胃内源性胃泌素释放；（３）抗生长抑素血清和前列腺素合成酶抑制剂消炎痛可阻断生长抑素对胃窦运动的抑制作用。上述结果提示：生长抑素的抑制作用除通过直接作用于生长抑素受体外，还可能通过胃窦局部前列腺素介导来抑制胃的运动。更多还原

【Abstract】 Effect of somatostath(SS)on gastric motility was studied on the preparation of isolatedvascularly perfused rat stomach. The results were as follows:(1)Vascular perfusion of SS(1μg/ml) markedly reduced amplitude of antral contraction by 30.0%±4.6%(P<0.05,n=5).(2)SS inhibited gastrin release significantly(48.3 %±15.8%,P<0.05,n=6) in the vascularperfusate。(3)Vascular perfusion of motilin(0.125μg/ml) excited isolated antral motilitysignifcantly. However, SS(1.0μg/ml)markedly inhibited antral motility stimulated by motilin,with decrease in amplitude of contraction by 21.4%±3.3%(P<0.05,n=5).(4)Antisomatostatinserum(1∶10)completely abolished the inhibitory effect of SS on antral motility.(5) Vascularperfusion of indomethacin(5μg/ml)completely blocked the inhibitory effect of somatostatin onantral motility. The results indicate that somatostatin inhibits basal antral motility in totally iso-lated vascularly perfused rat stomach.The inhibitory action of SS is mediated by the localprostaglandin in gastric antrum in addition to the direct action on SS receptors.更多还原