【摘要】 尼莫地平治疗兔右大脑中动脉闭塞５ｈ，明显降低脑钙积累６４％，降低脑Ｎａ、Ｋ、Ｈ２Ｏ转移分别为６４％、６７％、４０％；维拉帕米的上述作用分别为３９％、４８％、４５％、３９％，其降钙作用明显弱于尼莫地平；硫氮卓酮对离子和水的异常转移无明显改善。提示钙拮抗剂可能通过阻滞钙内流降低钙积累，并间接抑制离子和水异常转移，减轻离子性脑水肿。更多还原

【Abstract】 The effects of nimodipine,verapamil,and diltiazem at the dose of 10 μg/kg boluses and 0.5μg/kg. min given within 5h on the brain calcium accumulation,and the sodium,potassium ions and water shifts after middle cerebral artery occlusion in rabbits were studied. Nimodipine significantly reduced the calcium accumulation by 64%,and the sodium, potassium ions and water shifts by 64%, 67%, and 40% respectively. Verapamil decreased the items mentioned above by 39%,48%,45%,and 39%,respectively,and its effect of reducing the calcium accumulation was lower than that of nimodipine. There was no significant improvment in the ions and water shifts due to diltiazem. The results demonstrate that calcium antagonists can protect brain ischemia by reducing calcium ion enteririg ischemic cells,and indirectly reducing the sodium,potassium and water shifts in brain ischemic cells.更多还原