【摘要】 本文利用高效液相色谱法测定了８０例肺癌患者血清视黄醇含量，并以１００名正常人作为正常对照组，５０例糖尿病患者、４０例肺结核患者分别作为病理对照组。结果表明，肺癌组视黄醇含量１．６２±０．０２ｕｍｏｌ／Ｌ，显著低于正常对照组（２．３３±０．５８ｕｍｏｌ／Ｌ）、糖尿病组（２．４６±０．０１ｕｍｏｌ／Ｌ）和肺结核组（２．０６±０．１２ｕｍｏｌ／Ｌ），Ｐ＜０．０１。有５２．５％的肺癌患者处于视黄醇缺乏状态。血清视黄醇含量在鳞癌、腺癌和未分化癌三个病理类型间有逐渐下降的趋势。我们认为维生素Ａ类可以控制上皮细胞的分化，缺乏时即可增加了机体对化学致癌物的敏感性，发生癌的机率增大。更多还原

【Abstract】 Serum retinol of patients in lung cancer was measured in this thesis with the method of high pressure liquid chromato-graphy(HLPC).The results showed that the level of retinol of patients in lung cancer was 1.62μmol/L and significantly higher than those of normal and abnormal control groups(p<0.01).52.5%(42/80)patients in lung cancer were in the state of deficient retinol.The levels of serum retinol among three pathological types(i.e.sqamous carcinoma,adenocarcinoma,anaplastic carcinoma)were different.It suggests that vitamin A control the epithelial cell differentiation.The deficiency of retinol may increase host’s susceptibility to chemical carcinogen.Therefore, the subsequent risk of development of lung cancer is high.更多还原