【摘要】 对比研究了克山病病区和非病区儿童的硒状态，血浆血栓素和前列环素水平，血小板血栓素形成、聚集性和超微结构．发现：１．全血和红细胞硒水平低的病区儿童血小板谷胱甘肽过氧化物酶活性也显著低于非病区；２．病区儿童血浆血栓素显著高于非病区，而前列环素却无显著差异；３．用花生四烯酸刺激血小板时，病区儿童血小板聚集反应和血栓素形成均显著高于非病区；４．血栓素与聚集性呈显著正相关，两者分别与全血或红细胞硒水平呈明显负相关；５．病区儿童血小板形态明显异常，出现变形和团聚血小板，α－颗粒显著减少。结果提示病区儿童血小板处于活化状态，可能是克山病发病的一个危险因素。更多还原

【Abstract】 Selenium status. plasma thromboxane A, (TXA2) alld prostacyclin(PGI,). platelet TXA2 formation. aggregability and ultrastructure were comparatively investigated of children from Keshan disease endemic and non-endemic areas. It was found that: (1) Whole blood and erythrocyte selenium contents and platelet glutatathione peroxidase activities were significantly lower in children of the endemic area than of the non-endemic area: (2) The plasma TXA2 level was remarkably higher in children of the endemic area than of the non-endemic area.whereas plasma PGI2 levels were comparable in children from both the areas: (3) Platelets of children in the endemic area aggregated to a significant greater extent and produced larger amount of TXA2 than did the platelet from the non-endemic area when using arachidonic acid as stimulus: (4) Significant negative correlations between TXA2 level or platelet aggregability and whole blood or erythrocyte Se content were observed. and platelet aggregability had statistically significant positive correlation with platelet TXA2 formation: (5) Ultrastructurally.platelets from Iow-Se childrell showed signs of abnormalities as proved by the appearance of shape-changed and aggregated platelets and the decrease in the number of discoid platelets and α-granuales. The results indicate that platelets of children in the Keshan disease area appear to be in an activated status. which might be a risk factor in the pathogenesis of Keshan disease.更多还原