【摘要】 应用铬粒素抗体免疫细胞化学方法对２５例前列腺组织进行了研究，其中２１例前列腺癌，４例前列腺增生。发现８例（３８．ｌ％）癌组织中含有神经内分泌细胞（ＮＥ细胞），其中血清素阳性４例，胰高血糖素阳性２例。用前列腺特异性抗原（ＰＳＡ）标记２５例前列腺组织及７例非前列腺组织。发现ＰＳＡ表达与前列腺癌分化有一定的关系，在高、中分化腺癌中，ＰＳＡ的染色较低分化腺癌强。高、中分化腺癌染色类型为腔缘型，低分化腺癌为胞浆或胞膜型。更多还原

【Abstract】 n 21 cases of prostate adenocarcinoma and 4cases of prostate hyperplasia, neuroendocrine (NE)cells were studied immunohistochemically withanti-chromogranin antibody. NE cells were detectedin 8 cases (38.8%), in which 4 were found positive forserotonin and 2 for glucagon. 25 cases of prostaticspecimens and 7 cases of nonprostatic adenocarcinomas were labelled with prostate-specific antigen(PSA). It was shown that expression of PSA was close-ly correlated with differentiation of prostaticadenocarcinomas. Reaction of PSA was stronger inwell-moderately differentiated adenocarcinoma thanin poorly differentiated one. For staining pattern, pos-itive reaction of PSA was located in the apical borderin well-moderately differentiated adenocarcinoma,but in the cytoplasm and cell membrane in poorly dif-ferentiated one.更多还原