【摘要】 为了解激素敏感型肾病综合征是否有免疫遗传学背景,我们用病例一对照研究的方法研究了该病的家族遗传情况及HLA抗原频率。患者组父母患病率（0.62%）与对照组（0.14%）比较差异无显著性。HLA-DR7抗原频率患者组为40.0%,对照组为11.23%(P=2.5×10^-4)。患者组的HLA-DQ1抗原频率较对照组有显著性下降(P=6.5×10^-3)。比较了8岁前与8岁后起病的患者的HLA抗原频率,未发现有显著性差异。更多还原

【Abstract】 To determine whether steroid-sensitive nephrotic syndrome has an immunogenetic basis, we used the case-control method to study the familial transmission and HLA antigens in steroid-sensitive nephrotie syndrome patients. The difference between the prevalence rate of the disease in parents of the cases （0.62%） and that of the controls （0.14%） did not reach statistical significance. HLA-DR7 was found in 40.0% of the patients, compared with 11.23% of the controls (P=2.5×10^-4). HLA-DQ1 was significantly decreased (P=6.5×10^-3)in patients. HLA antigens were not significantly different in patients with onset of the disease before the age of 8 years compared with older children.更多还原