【摘要】 我们对７６例急性白血病（ＡＬ）患儿进行了骨髓细胞姐妹染色单体交换（ＳＣＥ）频率的动态观察和分析。结果显示：初发组、部分缓解（ＰＲ）组ＳＣＥ频率增高，与完全缓解（ＣＲ）组比较均有非常显著的差异（Ｐ＜０．０１）。与对照组相比，ＣＲ组ＳＣＥ频率仍高干对照组（Ｐ＜０．０５）。持续完全缓解３年以上者ＳＣＥ频率与对照组比较无显著差异（Ｐ＞０．０５）。表明：ＡＬ患儿治疗前骨髓细胞的ＳＣＥ水平损伤严重；ＣＲ时其损伤仍未完全修复，随着病情进一步好转，ＳＣＥ频率亦趋于正常。无标记型急性淋巴细胞白血病（ＮｕＬＬ－ＡＬＬ）患儿达ＣＲ时，ＳＣＥ频率仍高于普通型急性淋巴细胞白血病（Ｐ＜０．０５），表明不同类型的ＡＬ，ＤＮＡ损伤程度和恢复速度亦不同。更多还原

【Abstract】 he sister chromatid exchange (SCE) frequency ofbone marrow cells in 76 cases of acute leukemia including46 acute lymphocytic leukemia (ALL) and 30 acute non-lymphocytic leukemia (ANLL) and 21 normal controlswas studied. SCE frequency was the highest prior totreatment, decreased when partial remission (PRi , andsignificantly declined when complete remission (CR).There was no difference in SCE frequency between pa-tients who had been CR over 3 years and nornial con-trols. SCE frequency between the null-ALL group andthe c-ALL group (in CR) was significant difference.The study suggested that dynamic observation of theSCE frequency might be helpful in monitoring the statusof the illness, determining the therapeutic effectivenessand predicting the prognosis.更多还原