【摘要】 应用氨氯地平(Amlodipine)与尼群地平(Nitrendipine)对120例轻、中度原发性高血压患者采用随机单盲平行组间对照法进行临床研究。结果显示:①氨氯地平总有效率90％,尼群地平总有效率80％,差异无显著性意义(P>0.05);②氨氯地平的降压幅度大于尼群地平,但仅舒张压降低幅度的比较有统计学意义(P<0.01);③对心率、血象、血糖、血脂、血尿酸、血清电解质和肝、肾功能均未发现不良影响;④氨地平半衰期较长,降压作用较持久,每日只需服用1次(5或10mg),较尼群地平更为方便。更多还原

【Abstract】 Amlodipine which has the similar chemical structure to nitrendipine is the third generation of calcium antagonist. It is used in some countries for treating hypertension and myocardial ischemia with a good effect. 120 patients with primary hypertension were selected, stage I and II are 60 cases respectively, male : femele=l:1, the range of ages is 27-65. The patients were randomized into 2 groups (Group A:amlodipine, n=80;Group B:nitrendipine, n=40). Group A takes amlodlpine 5-10mg once a day. Course of treatment is 4 weeks.Total efficiency of Group A is 90%, Group B 80% (P>0. 05). The decrease of BP in Group A is 27. 65±10. 82/15. 22±6.13mmHg; Group B 23. 53±12. 15/11. 93±5. 60mmHg. The decrease of dias-tolic pressure between 2 groups is prominent, P<0.01. There are no side effects of both drugs on heart rate, blood tests, blood glucose, lipid, uric acid, electrolytes, hepatic and nephritic function, and no postural hypotension. T1/2 of Amlodipine is 35-50 Hrs. It is more convenient than Nitrendipine for taking one time per day.更多还原