【摘要】 为了探讨天然牛黄形成机制，对１０例形成天然牛黄的胆囊和１例健康牛胆囊进行了病理组织学、组织化学和超微病理学研究。结果发现：形成天然牛黄的胆囊均有不同程度的炎性反应，多数表现为慢性腺体增殖性胆囊炎，个别为慢性胆囊炎的急性发作型。胆囊腺体分泌机能增强，分泌物以粘蛋白和粘多糖为主，尤其硫酸化糖蛋白分泌增多构成了牛黄形成的网状支架，从而促进牛黄的形成。电子显微镜观察结果证实牛胆囊炎发生时，不仅腺体和腺细胞数量增加，而且腺上皮中粗面内质网和分泌颗粒也明显增多。通过观察，我们认为所采集标本中慢性腺体增殖性胆囊炎主要由化学性致病因素、生理性因素以及其它因素所致，未见细菌性感染迹象。更多还原

【Abstract】 In order to investigate the formation mechanism of natural Gallstone, 10 ox-gallb-ladders with natural gallstone and one control were observed with the methods of histo-pathology histochemistry and ultrapathology. It was found that all the gallbladders hadinflammation reaction in different degree. Most of the cholecystitis were chronic withhyperplasia of glands. Few of them were acute attack of chronic cholecystitis. The sec-retion of glands enhanced, and the secretion were mainly mucin and mucopolysacchards.Especially, the secretion of sulfated glycoprotein increased. They could consitute the net-work of the stone. The study of E. M. showed that when cholecystitis occurred, not onlythe number of glands and the gland cells increased, but also the number of RER andsecretory granules of gland cells increased. Through the study, we thought that all ofthe cases were caused by chemical, physiological and other factors. There was no signof bacteria infection.更多还原