【摘要】 回顾性分析３３例ＨＦＲＳ患者肾组织超微结构改变，发现有以下特点：①血管内皮细胞损伤发生早，范围广，且以急性病变为主；②疾病晚期以慢性增生性病变多见；③肾小球、肾小管基膜及肾小球囊壁中均见稀疏分布、低密度的电子致密物，它们的出现与病程、病情轻重无明显关联。作者认为，病毒及免疫性损伤对ＨＦＲＳ均有致病作用。更多还原

【Abstract】 e investigated the renal ultrastruc-ture features in 33 patients with HFRS. Ev-idence of the presence of virus was notfound in EM fields. There were sorne char-acters under EM : ①Endothelial damage wasfound in the early stage of disease, and thelesions were often showed diffuse and activ-ity; ② Chronic, Proliferative lesions withHFRS were found in the late stage of dis-ease; ③ Scanty, low density deposits werepresent in glomerular basement membrane,tubular basement membrane and also thewalls of Bowman’ s capsule. There was nosignificant correlation between course,severity of the disease and the deposits. Wesuggested the virus and the immune com-plexes might play a role of pathogenesis.更多还原