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Protein Crystal Growth in Microgravity

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【作者】 毕汝昌； 桂璐璐； 师珂； 王耀萍； 陈世芝； 韩青； 胡永林； 沈福苓； 牛秀田； 华子谦； 卢光莹； 张健； 李松林； 龚为民； 牛立文； 黄其辰；

【Author】 BI Ru-Chang GUI Lu-Lu SHI Ke WANG Yao-Ping CHEN Shi-Zhi HAN Qing HU Yong-Lin SHEN Fu-Ling NIU Xiu-Tian Institute of Biophysics,Academia Sinica,Beijing 100101,PRC Department of Biology,Peking University,Beijing 100871,PRC Department of Biology,University of Science and Technology of China,Hefei 230026,PRC Department of Chemistry,Peking University,Beijing 100871,PRC

【机构】 Institute of Biophysics,Academia Sinica,Beijing 100101,PRC； Department of Biology,Peking University,Beijing 100871,PRC； Department of Biology,University of Science and Technology of China,Hefei 230026,PRC； Department of Chemistry,Peking University,Beijing 100871,PRC；

【摘要】 <正> Protein crystal growth is quite important for the determination of protein structureswhich are essential to the understanding of life at molecular level as well as to the development of molecu-lar biotechnology.The microgravity environment of space is an ideal place to study the complicated pro-tein crystallization and to grow good-quality protein crystals.A number of crystal-growth experiments of10 different proteins were carried out in August,1992 on the Chinese re-entry satellite FSW-2 in spaceusing a tube crystallization equipment made in China.A total of 25 samples from 6 proteins producedcrystals,and the effects of microgravity on protein crystal growth were observed,especially for an acidicphospholipase A2 and henegg-white lysozyme which gave better crystals in space than earth-grown crys-tals in ground control experiments.The results have shown that the microgravity in space favors the im-provement of the size,perfection,morphology and internal order of the grown protein crytals.

【Abstract】 Protein crystal growth is quite important for the determination of protein structures which are essential to the understanding of life at molecular level as well as to the development of molecu- lar biotechnology.The microgravity environment of space is an ideal place to study the complicated pro- tein crystallization and to grow good-quality protein crystals.A number of crystal-growth experiments of 10 different proteins were carried out in August,1992 on the Chinese re-entry satellite FSW-2 in space using a tube crystallization equipment made in China.A total of 25 samples from 6 proteins produced crystals,and the effects of microgravity on protein crystal growth were observed,especially for an acidic phospholipase A2 and henegg-white lysozyme which gave better crystals in space than earth-grown crys- tals in ground control experiments.The results have shown that the microgravity in space favors the im- provement of the size,perfection,morphology and internal order of the grown protein crytals.

【关键词】 proteins； crystal growth； microgravity effect；
【Key words】 proteins； crystal growth； microgravity effect；
【基金】 the National High-Tech Program of China
  • 【文献出处】 Science in China(Series B) ,中国科学B辑(英文版) , 编辑部邮箱 ,1994年10期
  • 【分类号】O629.8
  • 【被引频次】1
  • 【下载频次】24
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