【摘要】 通过检测１１例高血压病（ＥＨ）、７例冠心病（ＣＡＤ）、８例对照组糖耐量前后胰岛素（ＩＳ）、Ｃ肽（ＣＰ）及其曲线下面积（ＡＵＣ）的变化，发现ＥＨ组与ＣＡＤ组空腹及服糖水后１、２、３小时血清ＩＳ、ＣＰ及其ＡＵＣ均高于对照组，服糖水后２小时值的差别具有高度显著性。还发现ＥＨ患者空腹血清ＩＳ水平与空腹甘油三脂水平呈正相关（ｒ＝０．６１，Ｐ＜０．０５）。提示ＥＨ及ＣＡＤ患者均可能有胰岛素抵抗（ＩＲ），且高胰岛素血症与脂质代谢异常有关。更多还原

【Abstract】 Insulin (IS), C-peptitide (CP) and their under the curve (AUC) weremeasured in 11 hypertensives, 7 patients of CAD and 8 control normotensives,Compared with the normotensives, the patients of CAD and the patients of EHshowed higher fasting and after the oral glucose load serum IS, CP and their AUC.During the OGTT, there is a significant difference in the CP, IS and their AUC at2 hour postload (P<0. 01). The correlationships between fasting serum iS and TG(r=0. 61,p<0. 05) were observed in patients with EH. The results indicated thatboth the patients with CAD. and the patients with EH have insulin resistant, andthere is a relationship between hyperinsulinemia and abnormalities of TGmetabolism.更多还原