【摘要】 以碘化－Ｎ－甲基－２－氯吡啶盐为缩合剂，在三乙胺存在下由３－（２－环戊酮基）丙酸及３－（２－环己酮基）丙酸分别同四氢噻唑－２－硫酮反应，得到新化合物Ｎ－（２－环戊酮基内酰基）四氢噻唑－２－硫酮（２ａ）及Ｎ－（２－环己酮基丙酰基）四氢噻唑－２－硫酮（２ｂ），产率分别为５２．９％和５１．０％，２ａ，ｂ分别同甲醇、乙醇反应得到相应的３－（２－环戊酮基）丙酸酯３ａ，ｂ及３－（２－环己酮基）丙酸酯３ｃ，ｄ，３ａ～ｄ的产率为７５～８７％；２ａ、ｂ分别同胺反应得到３－（２－环戊酮基）内酰胺４ａ、ｂ及３－（２－环己酮基）内酰胺４ｃ、ｄ，４ａ～ｄ产率为７８～９３％。更多还原

【Abstract】 The equiniolar reaction between 3-(2-cyclopentanoyl)propionic acid or 3- (2-cyclohex-anoyl)propionic acid and thiazolidine-2-thione with N-methyl-2-chloropyridium salt in the presence oftriethylaniine preduced the correspondins N ( 2-cyclopentanoyl propionyl ) thiarolidine- 2- thione 2a in52. 9% yield and N- (2-cyclohexanoyl propionyl)thiazolidine-Zthione 2b in 51% yield. Compound2a and 2b have not been reported in the literature.Compound Za and Zb reaet with methanol or ethanol in the presence of KzCOs at rcom tempera-rure to afford the corresponding esters 3a￣d in 75～87% yields.3- (2-Cycloketonyl)propionaniides4a￣d were easily prepared in sfor yields from the reactions between eompound Za,b and aniines.更多还原