【摘要】 实验对１日龄雏鸡接种ＭＤ三价疫苗或ＨＶＴ疫苗后的免疫应答变化进行了检测．发现ＭＤ疫苗免疫后：（１）脾脏、胸腺Ｔ细胞ＩＬ—２诱生活性和ＩＬ—２Ｒ表达明显增强或增多，表明ＩＬ—２的免疫调节作用增强；（２）胸腺、法氏囊和脾脏中Ｔ细胞和抗体生成细胞数量及Ｔ细胞增殖功能明显增高，表明中枢与外周免疫器官的细胞免疫和体液免疫应答显著增强；（３）盲肠扁桃体、哈德尔腺、支气管粘膜淋巴组织中Ｔ细胞和抗体生成细胞数量以及泪液、气管液、肠液、胆汁中ＩｇＡ，ＩｇＧ，ＩｇＭ含量明显增多，表明呼吸道与消化道的局部免疫应答也显著增强；（４）ＭＤ三价疫苗免疫鸡的上述免疫应答变化比ＨＶＴ疫苗免疫鸡明显．更多还原

【Abstract】 The experiment was undertaken to detect the immunoresponse of chicks inoculated with MD trivalent vaccine and HVT vaccine respectively.Following immunization,it was discovered that:(1)the IL- 2 inductive activity and IL- 2R expression in T cells from both of thymus and spleen were significantly enhanced, which indicates that the immunoregulativc level was elevated in immune organs;(2)the number and proliferative function of T cells in thymus and spleen and the number of antibody producing cells in Bursa Fabricius and spleen were increased markedly,which shows that the cellular and humoral immunoresponse was raised incentral and peripheral immune organs;(3)the numbers of T cells and antibody producing cells in cecal tonsil,Harder gland,mucosal lymphoid tissue of bronchus as well as the contents of IgA,IgG,IgM in tear, bronchea washings, intestinal secretions, bile were obviously raised too,which demonstrates that the local and mucosal immunoresponse was elevated inrespiratory and digestive tracts;(4)the abovementioned changes in chicks vaccinated with MD trivalent vaccine were demonstrated more markedly than those of chicks vaccinated with HVT vaccine.Note:This experiment is a part of the project supported by the National Natural Science Foundation of China.更多还原