【摘要】 在家兔内脏痛模型上观察了甲氧氯普胺（MCP）的镇痛作用。结果:MCP 8mg·kg^-1iv有明显的镇内脏痛作用.该作用可被多巴胺（DA）受体激动剂阿扑吗啡.D₁受体激动剂SKF38393.D₂受体激动剂LY171555 icv所拮抗。应用高效液相色谱—电化学检测法也观察到MCP8 mg·kg^-1iv20 min后.脑脊液中DA的代谢产物3-甲氧基-4-羟基苯乙酸明显升高。表明MCP的镇内脏痛作用与阻断脑内DA受体有关.D₁、D₂受体的激活均不利于MCP镇痛。更多还原

【Abstract】 The present study was to investigate the analgesic effect and mechanism of meto-clopramide (MCP) on a rabbit visceral pain model. The results showed that MCP (8 mg· kg-1,iv) could produce a significant analgesic effect on visceral pain (P<0.05). The analgesic effect of MCP could be antagonized by apomorphine, SKF 38393 (aselective D, agonist) and LY 171555 (a selective D2 agonist), respectively. Using HPLC-ECD, we also foundthat the HVA content in CSF significantly increased 20 min after MCP(8 mg·kg-1iv)(P< 0.05). These results indicate that MCP has an analgesic effect on visceral pain. The analgesic effect is related to the blockade of the central DA receptor. The activations of the D1, D3 receptor are unfavourable to MCP analgesia.更多还原