【摘要】 17只1日龄肉用小公鸡,饲喂低水平核黄素日粮(1.65mg/kg),于22～28日龄间有29.4％出现典型的“卷趾”麻痹症状。光镜观察,坐骨神经纤维雪旺氏细胞肿大、增生、酸性磷酸酶活性增强和髓鞘变性。严重病例的坐骨神经显著肿大,神经纤维分离,间质水肿和炎性细胞浸润。电镜观察,坐骨神经有髓神经纤维的髓鞘扭曲、分层、破碎、形成同心圆层状小体,神经轴膜与髓鞘分离形成间隙和神经轴索变形。雪旺氏细胞胞浆中见同心圆层状小体和空泡。无髓神经纤维未见异常。更多还原

【Abstract】 17 day-old male broilers were fed with low riboflavin diets (1.65mg/kg). 29.4% of them showed typical "curled-toe" paralysis symptom within 22-28 days. Microscopic lesions were Schwann cell swelling and proliferation, and increase of acid phosphatase enzyme activity, and demyelination in the affected sciatic nerve fibers. Marked edema, nerve fiber separation, interstitial substance swelling and leukocytic infiltration of the sciatic nerve tranks were seen in severe cases. Ultrastructural studies indicated that the myeline sheaths of affected sciatic nerves were twisted, separated, broken, or in the form of concentric circles lamellae-like myeline bodies, and that spaces or vacuoles were seen between the adjacent axolemmas and myeline membranes. The nerve axis-cylinder shapes were changed. Concentric circles lamellae-like myeline bodies and vacuoles were seen in the cytoplasm of Schwann cells. Nonmyelinated nerve fiber remained intact.更多还原