【摘要】 为了寻找静息状态下评价心泵储备功能的方法,本实验利用不同累积量阿霉素造成大鼠不同程度的心功不全,观察了左心室收缩性、舒张性、顺应性,以及在静息和负荷状态下心泵功能的变化。实验表明,随着阿霉素累积量的增加,大鼠心肌组织损伤程度加重;左心室收缩、舒张、顺应性和心泵贮备功能各指标均明显降低。但是,由于心外因素的影响,静息心泵功能指标有不同程度的增加。逐步判别分析表明,用判别函数方程,即综合分析静息状态下左心室舒、缩和顺应性能的变化,与用心泵贮备功能进行心功分级的结果基本一致。多元逐步回归分析亦表明,心功不全的不同阶段,心脏收缩、舒张和顺应性对心泵贮备功能的影响不同。更多还原

【Abstract】 To find out the method of assessing the car-diac reserve function under the resting condition,we observed the changes of left ventricular con-tractility, relaxation and compliance, as well ascardiac pump function under the resting and over-loaded conditions with intact hearts of male rats invarious states of heart failure induced by variousadriamycin cumulative doses. The results of thepresent study indicated that the degree of my-ocardium injury was aggravated along with the in-crease of adriamycin cumulative doses. Mean-while, all of the parameters of left ventricular con-tractility, relaxation, compliance and cardiac re-serve function decreased significantly. However,the indexes of basic cardiac pump function in-creased to a certain extent because of the influenceof non-cardiac factors. The discriminant analysisshowed that the degree of heart failure assessed bymeans of the discriminant function, or synthesizingthe changes of left ventricular contractility, relax-ation and compliance under the resting condition,was almost consistent with that by means of thecardiac reserve function. In addition, the multipleregression indicated that the contractility, relax-ation and compliance had different effects on thecardiac reserve function, corresponding to the different states of heart failure.更多还原