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冠心急救丹治疗冠心病临床疗效及毒性试验观察

Efficacy and Safety of Guanxinjijiu Dan in the Treatment of Coronary Heart Diseases

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【作者】 吴汉卿; 何美冬; 胡少明; 杨芙蓉; 钱振坤; 蔡玉祥; 杜佐华; 周际安;

【Author】 Wu Hanqing, He Meidong, Hu Shaoming et alDepartment of Tranditional Chinese. Medicine, Tongji Hospital,Tongji Medical University, Wuhan 430030

【机构】 同济医科大学附属同济医院中医科; 同济医科大学附属同济医院药厂; 同济医科大学基础医学研究所临床药理研究室; 同济医科大学基础医学研究所临床药理研究室 武汉 430030; 武汉 430030; 武汉 430030;

【摘要】 采用冠心急救丹与消心痛随机分组单盲对照治疗冠心病92例。对缓解心绞痛有效率分别为 93.87%和 79、07%(P<0.05)。冠心急救丹无消心痛所引起的头晕、头胀痛等副作用,同时该药有降低血脂、血液粘度和部分改善微循环的作用(P<0.05和<0.01)。经动物急性毒性试验证明,冠心急救丹口服安全度大,几乎无毒。

【Abstract】 The efficacy and safety of guanxinjijiudan (GXD) and isorbide were compared in a single-blind, randomized paralleled study. Ninty-two cases of coronary heart disease divided into 2 groups were given GXD and isorbide respectively. After the treatment, the patients in the GXD group exhibited a greater degree of alleviation in angina pectoris than did those in the isorbide group, the effectiveness rate being 93. 87 % and 79. 07 % respectively. No side-effects were observed in the GXD group, whereas such side-effects as dizziness and fullness of head were frequently noted in the insorbide group. Moreover, GXD functions to decrease blood lipid, ameliorate blood viscosity and improve microcirculation. Its safety was also confirmed by acute toxicity experiment in rats

【关键词】 冠心急救丹; 冠心病;
【Key words】 guanxinjijiu,dan; coronary heart disease;
  • 【文献出处】 同济医科大学学报 ,Journal of Tongji Medical University , 编辑部邮箱 ,1993年05期
  • 【分类号】R242;R541.4
  • 【被引频次】1
  • 【下载频次】16
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