【摘要】 已经知道雌二醇可以引起c-myc原癌基因在大鼠子宫迅速和短暂的表达。我们的研究证实了雌二醇可以引起c-myc 原癌基因在切除卵巢大鼠的子宫表达,并且观察到一种抗雌激素—三苯氧氨(Tamoxifen)对c-myc 在子宫表达无明显作用,但它却能抑制雌二醇引起c-myc 增加的表达。更多还原

【Abstract】 7 β-Estradiol has been known to induce a rapid transient increasedexpression of c-myc gene in rat uterus.However,nothing is known aboutthe expression of c-myc in response of reproductive system to antiestrog-ens.Our study confirmed that estradiol induced expression of c-myc inovariectomized rat uterus,but did not significantly affect c-myc expressionin liver.Tamoxifen alone did not affect c-myc expression in uterus,butit inhibited the estradiol-induced c-myc expression in uterus.更多还原