【摘要】 本文研究了24例动脉粥样硬化性脑梗塞患者和39例正常对照载脂蛋白AI—CⅢ基因簇EcoRI限制性片段长度多态性及不同基因型与总胆固醇、甘油三酯和高密度脂蛋白胆固醇之间的关系。患者与正常对照组R₂等位基因频率分别为0.40和0.12,二组间具极显著性差异（P<0.0001）。R₁R₂基因型个体总胆固醇和甘油三酯高于R₁R₁基因型个体,而高密度脂蛋白胆固醇低于R₁R₁基因型个体。结果显示载脂蛋白AI—CⅢ基因簇遗传变异与动脉粥样硬化性脑梗塞有关,其机制可能是通过调控高密度脂蛋白所致。更多还原

【Abstract】 We have investigated the EcoRI restriction fragment length polymorphisms of the apolipoprotein AI-CⅢ gene cluster and the relationship among different genotype,total cholesterol(TC),trigl-yceride(TG),and high density lipoprotein choIesterol(HDL-C) in 24 patients with atherosclerosis brain infarction(ABI) and 39 healthy subjects.The frequency of the rarer R2 allele was 0.40 in patiens with ABI and this was higher than in the control group (R2 frequency 0.12,P< 0.0001).The individuals with the genotype R1R2 had significantly higher levels of TC and TG but lower levels of HDL-C compared those with genotype R1R1 The data showed that genetic variation in the apoAI-CⅢ gene cluster is associated with ABI,and that this mechanism may be associated with the modulation of the serum HDL-C.更多还原