【摘要】 4-氨基吡啶6mg/kg皮下注射能诱发小鼠的激怒反应,使小鼠出现攻击和殴斗行为.阿托品、东莨菪碱及酚妥拉明、普茶洛尔均无拮抗作用.利血平小剂量连续给药7天,或大剂量一次给药有拮抗效果.苯丙胺、金刚胺、左旋多巴及阿扑吗啡均能增强4-氨基吡啶的激怒效应.结果表明,4-氨基吡啶诱发小鼠的激怒反应与该药增强多巴胺能神经的功能有关.更多还原

【Abstract】 4-Aminopyridine(4-AP) 6mg/kg sc has been proved to be able to cause rage reaction in mice. Atropine, scopolamine, phentolamine and propranolol exerted no antagonistic effect on 4-AP induced rage reaction while reserpine could supress this response. Amphetamine, amantadine, 1-dopa and apomorphine at lower doses might potentiate the rage inducing effect of 4-AP. Moreover, amphetamine, amantadine, 1-dopa given alone at higher doses also evoked rage reaction similar to that induced by 4-AP. These findings, in conjunction with the inhibitory effect of chlorpromazine and haloperidol on 4-AP induced aggressive behavior reported in a previous paper, suggest that the activation of DA receptor is an essential requirement for eliciting this peculiar response. Therefore, it may be deduced that 4-AP induced rage reaction in mice results from increased release of DA by 4-AP from dopaminergic nerve endings in the limbic system and other sites.更多还原