【摘要】 本实验在大鼠右心室乳头肌上观察辅酶 Q₁₀在预防异丙基肾上腺素（异丙肾）所致心肌损伤细胞电活动的影响。异丙肾可影响心肌细胞去极化和复极化过程,使 APA、OS 和 RP 降低、APD 延长、Vmax 下降;辅酶 Q₁₀可减轻异丙肾对心肌细胞的电效应,使 APD 缩短、特别是 APD₅₀的缩短尤为明显。实验结果表明:辅酶 Q₁₀对心肌的保护作用,可能与阻滞细胞膜慢通道、减少细胞内钙负荷有关。更多还原

【Abstract】 Protective effect of Co Q₁₀ on the myocardial electrical activities wasobserved on the papillary muscle cells of isoproterenol （ISO）-inducedmyocardial injury in rats.ISO decreased APA,OS,RP and Vmax,prolongedAPD;Co Q₁₀ can reduce the electrical response of ISO on the myocardialcells.It shortened the APD,the APD₅₀ especially obvious.The experimental results showed:Blocking slow channel decreasingcellular calcium load may be one of the important ways in the protectiveeffect of the Co Q₁₀ on the myocardium.更多还原