【摘要】 本文报道两组接受庚酸睾酮(TE200mg/周16个月)正常育龄男子的精液分析、血清生殖激素、精子特殊功能的动态变化。结果:第一组(8名)血清 FSH、LH 和 T 给药前平均自身对照值分别为2.7、6.2IU/L和16.5nmol/L,注射后3、6、9、12个月 FSH 下降了63％;LH 下降了69.4～72.6％;T 升高176％～198％。平均经117.5±2.87天治疗后全部受试者均达到无精症,连续给药1年的女方无妊娠。3种激素在停药3个月后恢复到给药前水平,精子计数10～12个月恢复到正常范围。第二组(16名)在给药第一个月后精子计数开始下降的同时3种精子特殊功能均有显著下降,而同期精子活动率(a+b)却无显著改变。我们的结果表明:(1)同一剂量和疗程的 TE 导致中国人的无精于发生率远高于白种人,(2)这一激素方法是有效、可靠和可逆的男性避孕措施,(3)TE 的避孕机理除抑制精子发生外,似还有精子功能的早期损伤的抗生育效应。这一机理不同于 GnRH 拮抗剂(Nal-glu),后者仅降低精子计数和活动率,而无精子多元运动速度指标的任何改变。更多还原

【Abstract】 This paper reports the dynamic changes of semenanalysis,hormonal profile and sperm functions beforeand during weekly intramuscular injection of testos-terone enanthate(TE),200mg for 16 months.In thefirst 8 subjects the mean serum FSH,LH,and T levelsbefore injection of TE were 2.4,6.2 IU/L and 16.5nmol/L respectively.FSH decreased by 32.0～35.0%and LH by 27～29% of baseline levels,while T in-creased to 189～202% of baseline measured at 3,6,9,12 months during injection of TE.The mean durationrequired for achieving azoospermia was 117.5 4±2.87days.No pregnancy occurred during 12 months of TEadministration with no other contraceptive method.After cessation of treatment in all azoospermic men thethree reproductive hormones returned to pretreatmentvalues in 3 months,while full recovery of spermcounts required 10～12 months.In another group of 16 volunteers treated with thesame steroid regimen,sperm concentrations started todecrease in the 4th week with no change of mean motil-ity(grade a+b).Sperm motion multiparameters(SMP),zona free hamster oocyte penetration(HOP)and sperm-cervical mucous interaction(SCMI) wereseriously impaired in the first month after treatment,as compared to the controls.Our results demonstrated that TE induced a-zoospermia in Chinese men was much higher than thatin Caucasians.This hormonal regimen has proven tobe an effective,reliable and reversible male contracep-tive.Regarding to the contraception mechanism of TEin addition to suppression of spermatogenesis,thereseems to be an additional independent antifertility ef-fect of detective sperm functions,which is differentfrom that with GnRH antagonist plus TE that causesonly decrease of sperm count and motility but did notchange the SMP.更多还原