【摘要】 本文对单纯注射抗-Thy-1血清以及注射抗-Thy-1血清后又分别注射 IFN-γ和 TNF 的三种不同大鼠系膜增殖性肾炎模型进行了观察,发现 IFN-γ和 TNF 均能使抗-Thy-1血清诱发的系膜损伤模型的增殖病变更明显、持久。这一改进的系膜增殖性肾炎模型弥补了抗-Thy-1血清模型系膜增殖病变轻,且有自限性的不足,使其更适合于系膜增殖性肾炎的实验观察及治疗试验。更多还原

【Abstract】 The Thy-1 antigen is known as the cell surface antigen of the mouse thymocyte and is found to be expressed also on the rat mesangial cell membrane.A single intravenous administration of anti- Thy-1 antibody induces mesangi01ytic destruction of the glomerular structure resulting from the mesangial proliferation,but it is a self-limited proliferative model and the proliferative changes of mesangial are slight.In order to make this model useful for studying the mesangial proliferative glomerulonephritis in human,we administered r-IFN and TNF to rats after anti-Thy-1 antibody injection.It was found that r-IFN and TNF could increase the infiltration of polymorphonuclear leukocytes in glomeruli and mesangial cell proliferation,in addition it also made the continous mesangial change possibly.This modified model is a useful tool in the study of pathogenesis and evaluation of therapeutic effect of some medicine in mesangial proliferative glomerulonephritis.更多还原