【摘要】 本文用G显带方法对9名慢性乙型肝炎活动期患者的染色体进行分析,发现其染色体数目畸变率和结构畸变率都明显高于对照组。而结构畸变中的断裂点分布是非随机的,其中9号和11号染色体断裂点明显高于预期值,主要集中在9q11和11q13,而这些位点恰好和染色体脆性部位及癌基因座位有关。表明人体在乙型肝炎病毒(HBV)长期慢性感染下,可以产生各种类型的染色体畸变,而某些特定类型的染色体畸变可能是导致乙肝向肝癌转化的一个重要因素。更多还原

【Abstract】 G - banded chromosome analysis was carried out in the peripheral lymphocytes collected from 9 patients with hepatitis B and 10 normal controls. The results showed that the frequencies of chromosomal structural aberration (8. 22%) and numerical aberration (18. 81 %) in the hepatitis group were significantly higher than those (1.66%, 5.46%) observed in the control group. The distribution of the breaking sites among chromosomes were non - randomized. The number of the breaking sites observed in chromosome 9 and chromosome 11 was higher than expected. These were mainly located at 9qll and Ilql3. The results indicated that patients with chronic hepatitis B viral infection might have various kinds of chromosomal aberrations, some of which may play an important role leading to hepatocellular carcinoma.更多还原