【摘要】 血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7％和84％。50％的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z抗原与EBV复制相关,故IgG/Z抗体对鼻咽癌不仅有诊断意义,还可能有预后的意义。更多还原

【Abstract】 Out previous works had demonstrated that EBV IgA/VCA, IgA/EA, IgA/MA and IgA/EBNA-1 antibodies are specific and valuable for naso pharyngeal carcinoma( NPC )diagnosis,and that EBV is activeted in NPC patients. ZEBRA antigen[2], the product of BZLF, switches the EB virus from a latent to a replicative cycle. We detected antibody to ZEBRA in sera from patients with NPC, infectious mononucleosis ( IM ) and Bur kitt lymphoma ( BL ) . 293 cells transfected with plasmid containing BZL F1 fragment were used as target cells. Sera were tested by immunofluores cence test. Antibody titer≥10 was considered to be positive. The positive rates of IgG/Z antibody in sera from NPC,IM,BL patient and normal individuals were 85.7%, 84%, 50% and o, respectively. Interestingly there was no IgG/Z antibody in sera from normal individuals, and the positive rate of IgA/Z antibody was very low ( 14.2% ) in NPC patients. These results indicate that EB virus in NPC and IM patients is more active in replicative cycle and this antibody may be a useful marker for the early diagnosis of NPC. The significance of Z antibody in NPC, IM and BL patients was discussed.更多还原