【摘要】 本文用人体外周血淋巴细胞微核和姐妹染色体互换试验研究酸角的抗突变作用。全血经⁶⁰Cor射线照线,37℃温育2h后加酸角培养,微核发生率比阳性对照组显著降低,有剂量-反应关系,最高剂量组降低了3.65倍。全血、丝裂霉素C、酸角同时加入,4℃放3h后培养,微核发生率和姐妹染色单体互换频率比阳性对照组明显降低,剂量-反应关系明确,最高剂量组分别降低了2.30和0.85倍。结果表明,酸角对丝裂霉素C和⁶⁰Cor射线所致人体细胞的遗传损伤有阻抑和修复作用。更多还原

【Abstract】 Antimutagenici effects of tamarind were studied with micronucleus and sister-chromatid exchange tests in human peripheral blood lymphocytes. When the whole blood, irradiated by 60Co and incubated for 2 hours at 37℃, was cultured with tamarind, the micronucleus rate decreased remarkably as compared with positive control, showing a dose-response relationship, and it decreased by 3.65 times at the highest dose group. When the whole blood, mitomycin C and tamarind were added in medium simultaneously,and then the media were cultured after they had been disposed of at 4℃ for 3 hours, both micronucleus rate and sister-chromatid exchange frequency decreased remarkably as compared with positive control, showing a dose-response relationship, decreased respectively by 2.39 and 0.85 times at the highest dose groups.The results showed that tamarind had preventive and repairative effects upon the genetic damage in human cells caused by mitomycin C and 80Co.更多还原