【摘要】 <正> 岩参(Bergenia purpurascens)又名岩白菜,为虎耳草科植物,主产于西南地区,生长在海拔1000～3000m背阴面岩坡上.按中药炮制加工工艺将岩参制成药片,在四川省阆中、盐亭两县对食管癌高发区的食管上皮细胞增生和上消化道炎症患者1万多人进行长达5年多的治疗观察,治愈率达88.7％,表明岩参对上消化道炎症疗效显著,是一种具有开发前景的新药.作者在对岩参进行了一系列急、慢性毒性实验的基础上,进行微核试验、染色体畸变、SCE频率和DNA合成抑制实验,为岩参的进一步开发应用提供了理论依据.更多还原

【Abstract】 Bergenia purpurascens tablets were prepared according to the technological requirements of Chinese traditional medicine. Using these tablets to patients with esophageal epithelial cell proliferation and inflammation for five years in Lang. Zhong and Yan Ting Counties, Sichuan Province, a cure rate of 88.7% was achieved, demonstrating that Bergenia purpurascens is a new and promising drug. However, in order to determine whether or not long period of administration will induce mutagenesis carclnogenesis, we carried out micronucleus, chromosemal aberration and sister chromatid exchange frequency tests. The results showed that the drug neither induces micro-nucleus formation nor chromosomal aberration and SCE. Therefore, we conclude that this drug is safe and without toxic side effects.更多还原