【摘要】 本课题观察了高镁饮食对大鼠缺氧性肺血管收缩反应（HPV）和慢性缺氧性肺动脉高压的影响。大鼠进高镁饲料（每公斤普通饲料加镁1000mg）10周后,血浆镁浓度为2.58mEq/L,显著高于对照组大鼠的血浆镁浓度。慢性常压缺氧（吸入气含10%O₂,每天8小时,连续14天）后,与缺氧对照大鼠相比,进高镁饲料盼大鼠的平均肺动脉压（Ppa）和肺血管阻力（PVR）较低,肺血管对缺氧的反应性（△PVR%）较低,同时右心室肥大也较轻。血粘度和红细胞比积在慢性常压缺氧后均增高,但进高镁饲料大鼠的血粘度和红细胞比积与缺氧对照组大鼠无差别。结果表明,镁可以降低PVR和HPV,从而缓解由慢性缺氧引起的肺动脉高压和右心室肥大。更多还原

【Abstract】 The effects of dietary magnesium on pulmonary vascular reactivity and chronic hypoxic pulmonary hypertension were assessed in rats. The rats were fed on a high magnesium diet or a regular diet begining 8 weeks before the start of normobaric hypoxia （10±1.0% O₂ Ventilation, 8 hours per day, 14 days）. The plasma level of magnesium Was significantly increased in the high magnesium group as compared to the control. Mean pulmonary arterial pressure, pulmonary vascular resistance and pulmonary vascular reactivity to hypoxia in the rats fed on high magnesium diet were markedly lower than that in the rats fed on regular diet. Hypertrophy of the right ventricle in the rats fed on high magnesium diet were significantly lower as well. Blood viscosity and hematocrit had no difference between the high magnesium group and the control. These findings suggested that dietary magnesium can attenuate basic pulmonary vascular resistance and hypoxic pulmonary vasoconstriction, and therefore can prevent the development of chronic hypoxic pulmonary hypertension and right ventricular hypertrophy.更多还原