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二甲苯吸入致小鼠肝损伤的观察与探讨

Observation and Discussion on the Hepatic Injury of Mice Inhaled xylene

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【作者】 柳杰何新凤王斗南

【Author】 Liu Jie et al

【机构】 牡丹江医学院组胚教研室牡丹江医学院组胚教研室

【摘要】 本文观察到吸入二甲苯后小鼠肝脏出现肝细胞浊肿、脂变、炎性浸润、枯否氏细胞增多及肝血窦,小叶间静脉轻度扩张等变化.电镜观察可见细胞质内有大量脂滴,溶酶体、线粒体均有不同程度的破坏,糖原减少,核膜不清等变化。提示长期接触二甲苯者应加强防护,避免慢性中毒。

【Abstract】 The changes of hepatocell cloudy swelling fatty degeneration, inflammatory infiltration, kupffer cell creasing and slight expansion in hepatic sinusoid a nd interlobular veins occur t?mice liver when they have intaken xylene.With electron microscope, damages of different degree in fat drops, lysosome and chondriosome among the cytolipin can be observed. We have also found other changes, for example, glycogen decreasing and nuclear membrane unclearing. The article also warned that people who are exposed to xylene in their work sho-ul d avoid being poisoned.

【关键词】 二甲苯浊肿线粒体血窦
【Key words】 mitochondriachondriosomelysosomeglycogenhepatic sinusoid kupffercellxylene.
  • 【文献出处】 牡丹江医学院学报 ,Journal of Mudanjiang Medical College , 编辑部邮箱 ,1991年02期
  • 【被引频次】1
  • 【下载频次】31
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