【摘要】 本文观察18例新生儿败血症及11例新生儿皮下坏疽IgG亚类变化,两组患婴的四种血清IgG亚类均低于对照组（p<0.01或<0.05）。体外用pwm诱导B细胞产生lg可见两组患婴除lgM如lgG₃,外,IgG₁、lgG₂及lgG₄,明显低于对照组（p<0.01或p<0.05）。患婴的PBMC对T细胞丝裂原PHA的增殖反应减弱,CD₄/CD₈比值下降。本文结果表明新生儿感染时T细胞功能系乱可致B细胞抗体生成能力下降。更多还原

【Abstract】 The patterns of IgG subclasses in 18 cases of neonatal sepsis and 11 cases of neonatal subcutaneous gangrene were studied. Compared with those in 18 age - matched normal controls, all serum IgG subclasses (including IgG1 ,IgG2,IgG3and Igg4)in the both groups of the patients were statistically decreased(P<0. 01or P<0. 05). The ability of in vitro iminunoglobulin biosynthesis was observed with Tcell dependent mitogen(pokeweed mito-gen). The results showed that the concentrations of IgG1 ,Igg2and Igg4 in the supernntants of 10 -day cultured peripheral blood mononuclear cbllsfrom the patients with sepsis and subcutaneous gangrene were, lower than thosefrom normal controls. The Lymphocyte proliferative response to PHA and ratio of CD4/CD8in the patients were also decreased significantly in comparison with the normal controls. It is suggested that T cell dysfunction in neonatal infections might be related to the abnormal IgG subclass productions.更多还原