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载脂蛋白对某些中、老年心血管疾病的诊断价值

DIAGNOSTIC VALUE OF APOLIPROTEIN IN SOME CARDIOVASCULAR DISEASES OF MIDDLE AND OLD AGE

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【作者】 毕敏明戴东生汪渊张葵周青曹玉珍

【Author】 Bi Minming et al, Department of Cardiology, Affiliated Hospital, Anhui Medical University, Hefei

【机构】 安徽医科大学附属医院心内科安徽医科大学附属医院心内科安徽医科大学生化教研组安徽省电力局卫生所

【摘要】 用单向免疫扩散法测定正常人96例和冠心病、高血压病、老年性主动脉瓣钙化及慢性胆囊炎患者共85例的血清载脂蛋白、TC、TG.HDL—C、LDL—C、VLDL—C。结果表明apo—AI的降低及apo—B值的升高不单是预测冠心病的指标,而且是预测动脉硬化的指标。apo—AI/apo—B比值的下降,与脂代谢紊乱有关或由其引起的疾病均可出现,因而血清载脂蛋白不能作为诊断冠心病的最好指标。

【Abstract】 Serum apoliprotein, TC, TG, HDL-C, LDL-C and VLDL-C were measured by single radio-mmunodiffusion in 96 normal subjects and 85 patients suffered from coronary heart disease CHD), hypertension, senile aortic calcification and chronic cholecystitis. It was shown that ecrease of apo-A1 and elevation of apo-B indicated not only as predictor ot CHD but also that f atherosclerosis as well. The reduction of the ratio between apo-A1 and apo-B would occur in ipid metabolic disorders and consequent diseases. So the determination of serum apo-liprotein ight not be the best diagnostic criterion of CHD.

  • 【文献出处】 安徽医学 ,Anhui Medical Journal , 编辑部邮箱 ,1991年02期
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