【摘要】 <正> 自然杀伤细胞(NK细胞)是体内细胞免疫功能的组成部份,在某些肿瘤和病原微生物感染中,起到免疫监视的作用。NK细胞能识别多种抗原,并有直接杀伤靶细胞的能力。因而NK细胞的杀伤作用与肿瘤的发生,发展,转移及预后均有直接关系。 阿片肽作为神经介质,它们是否参与调节NK细胞的杀伤功能,是近年来人们感兴趣的研究问题,有研究者提到亮氨酸脑啡呔(leucine enkephalin,LENK)和甲硫氨酸脑啡呔(methionine enkephalin,更多还原

【Abstract】 Spleen mononuclear cells of BABL/C mice and YAC-1 cells were used in this experiment. Leucine enkephalin or methionine enkephalin at time 0 was added to cell cultures and the amount of the enzyme lactate dehydrogenase released from lysed target cells was determined 22 hours after incubation. There were on average 41% （5% to 60.7%） and 63% （46.8% to 78%）enhancements of natural killer activity in the presence of leucine enkephalin (1×10^-（11）-1×10^-3mg/ml) and methionine enkephalin (1×10^-15～1×10^-3mg/ml) respectively. The results showed that opioid peptides can modify NK cell function.更多还原