【摘要】 新西兰免78只分成8组。试验组、M组和对照组分别静滴去甲肾上腺素（NE）1毫克/公斤、美索克新明或生理盐水。其余5组在NE之前分别给予酚妥拉明（R组）、心得安（P组）、美多心安（MP组）、育亨宾（Y组）以及（口派）唑嗪（PR组）。以半定量方法分析心肌病理损害程度,并测定心肌中糖酵解中间产物11项以及能量代谢产物。结果发现NE组心肌损害显著（P<0.01）;P组、MP组、Y组和M组心肌损害类似于NE组;R组和PR组则较NE组减轻（P<0.01）。NE组和MP组心肌尚有明显的代谢障碍,而R组则较接近正常。提示NE所致心肌损害中α受体,尤其α₁受体起了主要作用。作者等对其发生机理进行讨论,并提出新的假设。更多还原

【Abstract】 Seventy eight New Zealand rabbits were divided into 8 groups. NE, M, and control group were given norepinephrine （1mg/kg）, methoxamine or saline, respectively. The other 5 groups were given regitine （R group）, propranolol （P group）, metaprolol （MP group）, yohimbine （Y group） and prazosine （PR group） respectively before NE infusion.Myocardial injury was estimated with a semi-quantitative histological scoring system, and 11 intermediate metabolites in glycolysis and ATP, ADP, AMP, CP in myocardium were measured. Results showed that myocardial injury was observed in NE group （P<0.01）,as well as in P, MP, Y and M groups; group R and PR tended to have less myocardial injury in comparison with NE group. Metabolic dysfunction was found in NE and MP group, while group R showed a nearly normal glycolysis and energy metabolizm. Conclusion: α-adrenoceptor, especially α₁ receptor, plays the key role in development of NE-induced myocardial injury. As for its mechanism we put forward a new hypothesis.更多还原