【摘要】 本工作观察了大鼠肝刺激因子（HSS）对CCl₄损伤小鼠后,肝组织和血清脂质过氧化物丙二醛（MDA）及自由基清除剂谷胱甘肽（GSH）含量的影响。结果发现,HSS（0.1mg/g 体重,ip）可使CCl₄（10%,5ml/kg）中毒后48 h,肝组织 MDA 值的升高幅度明显降低（6.23±0.98/nmol/mg 蛋白vs.4.17±1.67nmol/mg 蛋白,P<0.005）,但血清MDA值的下降幅度不明显。同时肝组织GSH含量明显高于CCl₄损伤组（3236±472μg/g vs.2007±589μg/g,P<0.001）。上述结果提示,HSS具有抗氧化作用,降低CCl₄自由基对肝细胞膜的损伤作用,保护受损肝脏。更多还原

【Abstract】 Hepatic stimulator substance（HSS）was examined for its ability toinfluence on liver lipidperoxidation（LPO）characterized by MDA andGSH contents in blood and liver tissue in CCl₄-injured mice.Theresults were as follows:0.1mg/g of HSS at single dose 48h after theadministration of CCl₄（10%,5ml/kg）demonstrated a marked reductionof liver MDA content,the serial MDA was also slightly decreased.However,liver GSH content in HSS-treated mice showed 61% ofrecovery from that of CCl₄-injured mice alone,with transformation ofGSSG reduced.These results indicate that HSS might reduce liver LPOand also strengthen the endogenous antioxidative ability of CCl₄-injuredmice.更多还原