【摘要】 激活补体类HBsAg循环免疫复合物(HBsAg/C3-CIC )的检出率,与HBV复制标志的关系,在急慢性乙型肝炎病毒感染中表现不同。在慢性肝病(包括慢性迁延性乙型肝炎、慢性活动性乙型肝炎、乙型肝炎后肝硬化和HBV感染指标阳性的原发性肝癌)患者中,HBeAg阳性者,其HBsAg/C3-CIC的检出率显著高于HBeAg阴性者,且随HBeAgS/N值的升高而增加。在由HBV e系统组合成的四种模式中,单纯HBeAg阳性模式的检出率显著高于其它三种模式;在多聚白蛋白受体(PHSAr)阳性者中检出率显著高于PHSAr阴性者。而急性乙型肝炎(AH)的HBsAg/C3-CIC检出率无类似差异。这些结果提示,HBsAg/C3-CIC在HBV感染的急慢性肝病中具有不同的病理生理意义。更多还原

【Abstract】 Chronic hepatitis B infection differs from acute hepatitis B infection in the relationship between the positive rates of HBsAg/C3-CIC and the markers of HBV reproduction. In chronic hepatitis B infection, the positive rates of HBsAg/C3-CIC in the HBeAg positive samples were significantly higher than in the HBeAg negative ones and rose in parallel to HBeAg S/N values. The HBsAg/C3-CIC positive rates among PHSAr positive cases were significantly higher than those in the PHSAr negative samples. In cases which were HBeAg-positive alone, the HBsAg/C3-CIC positive rates were significantly higher than those in other types of the HBV e system. This difference did not exist in acute hepatitis B cases. The results suggest that the pathological and physiological significance of HBsAg/C3-CIC in chronic hepatitis B virus infection may differ from that in acute hepatitis B virus infection.更多还原