【摘要】 本文测定了健康儿童血和尿β₂微球蛋白（β₂m）正常值,观察了几种儿科常见肾脏病血和尿β₂m变化。在急性肾炎早期血β₂m可有轻度增高。肾病综合征和IgA肾病有少数病例血和/或尿β₂m增高。狼疮肾炎和过敏性紫癜肾炎部分病例血β₂m增高,而尿β₂m增高更显著。尿毒症病例血β₂m与血肌酐（SCr）、血尿素氮（BUN）呈正相关,与肌酐清除率（Ccr）呈负相关。尿β₂m测定肾小管功能较酚红排泄试验和莫氏试验敏感,并能反映出肾小管病理改变。更多还原

【Abstract】 In this study we measured the high limit value of blood and urine B2-microglobulin (β2m) in healthy children, and observed blood and urine β2m level changes in some common renal diseases in children. In early stage of acute glomerulonephritjs blood β2m of about 50% patients might increase slightly. In nephrotic syndrome and IgA nephropathy blood β2m increased in a few cases. In lupus erythematosus glomerulonephritis (LEGN) and anaphylactic purpura glomerulonephritis (APGN) the most of patients had increase of urine β2m. Blood β2m in uremic patients was positively correlated with blood creatinine and BUN, and negatively with Ccr. The level of urine β2 m reflexed the renal tubular function better than PSP test and Mosenthal’s test, and could show the severity of tubular and interstitial abnormalities. Our conclusion is that the level of blood and urine β2 m can represent the function of glome-rular filtration and tubular function in primary glomerulonephropathies, but can not help the diagnosis. Owing to higher level of urine β2 m in LEGN and APGN, it would be probable that measuement urine β2 m might provide referential value to the diagnosis of those diseases.更多还原