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海南省陵水及白沙等地区恶性疟原虫对磷酸喹哌的敏感性调查

IN VIVO SENSITIVITY OF PLASMODIUM FALCIPARUM TO PIPERAQUINE PHOSPHATE ASSAYED IN LINSHUI AND BAISHA COUNTIES, HAINAN PROVINCE

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【作者】 蓝昌雄; 林秀; 黄在松; 陈玉松; 郭仁能;

【Author】 Lan Changxiong, Lin Xiu, Huang Zaisong, Chen Yusong, Guo Renneng1. Second Institute of Parasitic Diseases, Hainan Province; 2. Sanitary and Anti-epidemic Station, Saisha County

【机构】 海南省第二寄生虫病防治研究所; 白沙县卫生防疫站; 海南省第二寄生虫病防治研究所;

【摘要】 1986年7~12月,在海南省陵水县吊罗山、白沙县元门乡、青松乡及三亚市南滨农场,治疗恶性疟病人53例,采用磷酸喹(?)1.5g(碱基),3d分服,退热时间为36.0±20.7h,原虫转阴时间为69.7±20.9h。治疗后经14、21和28d随访者47例,发现一级抗性7例,复燃率14.9%,治疗后带配子体者35例,配子体率74.5%,较以往报告的57.1与40%为高。

【Abstract】 Fifty-three cases of falciparum malaria in Linshui County, Baisha County and Sanya Municipality were treated with piperaquine phosphate at a total dose of 1.5gbase over 3 days in July to December, 1986. The mean defervescence time was 36±20.7h; the mean asexual parasite clearance time was 69.7±20.9h. At 14-28d follow-up lecrudescence was observed with asexual parasitemia in 7 of the 47 cases, showing RI resistance to piperaquine. Gametocytemia was positive in 35 cases (74.5%) during the follow-up period.

  • 【文献出处】 中国寄生虫学与寄生虫病杂志 ,Chinese Journal of Parasitology and Parasitic Diseases , 编辑部邮箱 ,1989年03期
  • 【被引频次】5
  • 【下载频次】25
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