【摘要】 鼠麻风杆菌(MLM)腹腔感染BALB/C和C57BL/6小鼠,随着感染时间的延长,鼠脾重量增加,脾带菌量增多,肠系膜病变加剧;鼠脾细胞对伴刀豆蛋白A(Con A)刺激的增殖反应和产生白细胞介素2(IL 2)的能力进行性降低,BALB/C鼠尤为严重。感染90d时在经Con A活化的BALB/C鼠脾细胞表面未检出IL 2受体,同时发现感染鼠脾细胞可以抑制正常鼠脾细胞经Con A刺激产生IL 2和表达IL 2受体的能力。推测感染鼠脾细胞免疫功能低下可能是该菌活化了抑制细胞,继而抑制T淋巴细胞合成和分泌IL 2和表达IL 2受体。更多还原

【Abstract】 Groups of BALB/0 and C57BL/6 mice were infected intraperitoneally with Myoobacterium lepraemurium (MLM) to establish an experimental model of MLM infection. It was found that the weight of the spleen and the number of MLM in the spleen increased progressively with intensification of pathogenic changes with increasing duration. At the same time, lymphoproliferative response and IL 2 activity generated by Con A-stimulated splenocytes from MLM-infected BALB/C and 057BL/6 mice were shown to be depressed progressively during infection, especially BALB/C mice. 90 days after infection, IL 2 receptors were not detectable on Con A-stimulated splenooytes by the IL 2 absorption assay. The splenooytes of the infected BALB/0 mice showed a suppressive effect on IL 2 production and IL 2 receptor expression of normal splenooytes. The above findings suggest that the depressed cellular immunity of infected mice is possibly due to MLM induced Suppressor cells which inhibit IL 2 production and IL 2 receptor expression of T lymphocytes.更多还原