【摘要】 对72例小细胞肺癌(SCC)及38例其他肺癌的石蜡材料,应用PAP法观察癌细胞对神经元特异性烯醇酶、S-100蛋白、促肾上腺皮质激素、降钙素、角蛋白及癌胚抗原的表达结果,提示SCC的组织发生和其他肺癌相同,也起源于支气管粘膜干细胞,文章并讨论了上述各种抗原检测在SCC诊断和鉴别诊断中的应用价值。更多还原

【Abstract】 Immunohistochemical differential detection of cancer cells in 72 cases of small cell carcinomas (SCC) and 38 oases of other types of lung carcinomas were studied. A peroxidase-anti-perosidase method was used with a series of antibodies against neuron-specific enolase, 8-100, ACTH, caloitonin, keratin, and oaroinoembryonio antigen. It was found that positive reactions of neuron-specific enolase in oellfl of various tumors were SCC 56/72, large cell carcinomas 3/4, oaroinoids 3/5, adenooar-oinomas 2/12 and squamous cell carcinomas 2/17. Eesults also showed that only oases of 800(8.3%) were stained by anti-keratin antibodies, 66.7% in adenooaro-inomas and 94.1% in squamous cell carcinomas were possitive respectively. The histologio origin of SCC and the signifioance of various antigens in the diagnosis of SCC were discussed.更多还原