【摘要】 本文报道30例胃粘膜活检印片细胞经Feulgen染色后,采用Opton-UMSP-30型显微分光光度计检测的结果。按DNA指数及含量分布直方图分析,28例胃癌中呈非整倍体型直方图者20例(71%),且在高或中分化腺癌中占多数(13/14、92.8%);而4例粘液细胞癌均属二倍体型。胃良性病变2例也为二倍体型。胃粘膜活检印片的制备较简便。用MSP测定其细胞DNA含量可作为诊断胃癌和癌前病变的一项有用的辅助指标,有利于胃癌的早期诊断及癌前病变倾向的预测。更多还原

【Abstract】 Microspectrophotometric measurement of nuclear DNA content was made on Feulgen stanined gastric biopsy imprints from 30 cases of patients with malignant or benign gastric disease. DNA aneuploidy was detected in 71% (20/28) cases of gastric carcinoma, and it was more frequently found in weel-or moderately differentiated adenocarcinomas of stomach (92.8%, 13/14), while diploid pattern was demonstrated in all 4 cases of mucous cell carcinoma as well as in 2 cases of benign gastric disease. It was suggested that MSP measurement of nuclear DNA content in gastric biopsy imprints may be used as an accessory parameter in clinicopathologic diagnosis of gastric mucosal biopsies, since it is a reliable and feasible method for the early diagnosis of gastric carcinoma and for the prediction of the malignant potential of gastric precancerous lesions.更多还原