【摘要】 系统地观察实验性动脉粥样硬化（以下简称AS）形成过程中血栓素A₂（TXA₂）/前列环素（PGI₂）平衡与血小板膜流动性的变化,探讨8501对前列腺素代谢及血小板膜流动性的影响及其在AS防治中的作用。结果发现,高脂组家兔在血清胆固醇含量明显升高的同时,血浆6-keto-PGF_1α水平显著降低,TXB₂水平显著升高,且前者降低先于后者增高,血小板膜流动性亦有所增加。8501除明显降低血脂外,还具有显著防止血浆6-keto-PGF_1α降低和TXB₂升高的作用,提示8501可能通过抑制TXA₂合成酶或激活PGI₂合成酶而发挥作用。更多还原

【Abstract】 The changes of TXA2/PGI2 balance and platelet membrane fluidity during experiment atherosclerosis formation and the effects of 8501 on these parameters in rabbits were investigated. The results indicated that while the serum cholesterol level was significantly increased in the cholesterol-fed group, the platelet membrane fluidity increased slightly and the level of plasma 6-keto-PGF1α was significantly decreased, but that of TXB2 was highly incr eased. However, the decrease of 6-keto-PGF1α appeared prior to the increase of TXB2. 8501 not only reduced the level of serum cholesterol but also prevented the decrease of 6-keto-PGF1α and the increase of TXB2 levels in plasma. This suggests that 8501 may inhibit the activity of TXA2 synthetase or stimulae the activity of PGI2 synthetase.更多还原