【摘要】 采用差速离心和去垢剂溶脱方法提取的电鳐电器官乙酰胆碱受体,与¹²⁵I标记的眼镜蛇神经毒素呈专一性和可饱和性的结合,广东蛇药针剂及某些外源性有机酸盐对这种结合表现为特异的竞争性抑制作用,提示广东蛇药的临床疗效可用此机理来初步解释,而以琥珀酸钾盐为主的有机酸盐则可能是其主要有效成分之一。更多还原

【Abstract】 The binding of 126I-neurotoxin (from Chinese cobra venom ) to solutive n-AChR from Narcine maculata electric organ showed a special, reversible course and could be saturated with excess the labeled neurotoxin. The authors found that Guangdong snake drug and some exogenous organic acid salts ( which present in the snake drug ) could specially compete with 125I-neurotoxin to the receptor. The most effective component was kalium salt of succinate. The results imply that the therapeutic efficacy and the effective component of Guangdong snake drug may be explained by this machanism and by kalium salt of succinate.更多还原