【摘要】 <正> 黄芪[Astragalus Membranaceus(Fish)Bge]是祖国医学中最常用的补益药之一,红芪(Radix Hedysari)与黄芪系同科异属,盛产于甘肃等地。中医用药红芪、黄芪不分,在西北地区尤为普遍。关于黄芪的免疫药理研究报道较多,而对红芪的研究尚在初始阶段。现已证明,红芪多糖对小鼠巨噬细胞的吞噬功能及E-花环形成率有明显的促进作用,但对体液免疫功能的作用尚未见报道。本文主要研究了红芪多糖和黄芪多糖对小鼠体液免疫功能的影响,并将二者平行实验进行比较,结果如下。更多还原

【Abstract】 The effects of radix hedysari polysaccharide (RHPS)and Astragli polysac-charide(APS)on immune function was studied in normal mice and in themice whose immune function had been suppressed by the use ofcyclophosphamide(CY)or prednisolone(PDS).RHPS or APS 500mg,1000mg/kg ip qd×6d to mice,could increase spleen weight(p<0.001).RHPScould decrease the thymus weight(P<0.01).Under electron microscopy moreplasmcytes and protien particles in the endoplasmic reticulum of the plasm-cytes were found in the spleens treated with RHPS than in those of thecontrol group.Both drugs could partialy counteract the decreasing effect onthe spleen and thymus weight coused by prednisolone.Tests of agglutinationand hemolysin proved that RHPS and APS did not markedly change thelevel of serum specific antibodies against SRBC in normal mice,but theycould significantly prevent the reduction of antibody level induced by a subcutaneous injection of CY (50mg/kg×1d)or PDS(25mg/kg×4d)(P<0.001).RHPS and APS also increased PFC of spleen in normal mice(p<0.01)atsame time antagonized inhibitory effect of CY(50mg/kg)(p<0.001),butcouldn’t correct the inhibitory effect of CY(100mg/kg). In conclusion,RHPS and APS play a regulatory and positive role on fluidimmune function in mice.更多还原